The invention relates to a wide voltage input and invariable voltage output power supply module, which comprises a protection circuit, a voltage conversion circuit and an invariable voltage output circuit, wherein the protection circuit is connected with the voltage conversion circuit through a filter circuit, the voltage conversion circuit is directly connected with the invariable voltage outputcircuit; the protection circuit consists of an overcurrent protection circuit and an EMC (Electro Magnetic Compatibility) protection circuit, the overcurrent protection circuit is connected with an input voltage, and is connected with the filter circuit through the EMC protection circuit. The wide voltage input and invariable voltage output power supply module has the advantages of reasonable structure, high reliability, strong practicability, wide voltage input, invariable voltage high-precision output, strong antijamming capability, high isolation voltage and high conversion efficiency, andcan be used under any worse electric environment. The overcurrent protection circuit can protect devices in circuits from being damaged when the input voltage generates overcurrent or short-circuit; by the protection of the EMC circuit, the noise and ripple waves in the input voltage can be reduced, and the antijamming capability is strong.