The invention discloses a method for preparing a clothing adhesive lining from self-crosslinking water-borne polyacrylate powderless base mud. The method comprises the following steps: at first, mixing water-borne polyacrylate emulsion, auxiliaries and deionized water, wherein the water-borne polyacrylate emulsion is prepared from pre-emulsion, seed emulsion, secondary emulsion, 10% adipic dihydrazide water solution and ammonia water, and the pre-emulsion is prepared from methyl methacrylate, butyl acrylate, acrylic acid, diacetone acrylamide, alkenamides sodium ethylenesulphonate, fatty alcohol-polyoxyethylene ether and deionized water; and then, adjusting the pH value of the system to be neutral with ammonia water, adding a water-borne acrylic thickener, and adjusting the viscosity to be less than 30,000. Soap-free emulsion prepared from lyophobic and hydrophilic monomers through a core-shell emulsion copolymerization technology is applied to the powderless base mud, so that the product has cleaner characteristics in preparation process and the product itself, meets green, environmental-friendly and healthy requirements, and conforms to the historical trend of the time.