The invention discloses weather-resistant printing ink, a manufacturing method and a testing method thereof, and the weather-resistant printing ink is mainly prepared from the following raw materials in parts by weight: 40-60 parts of polyacrylate oligomer, 8-15 parts of reactive diluent, 4-10 parts of photoinitiator, 10-15 parts of pigment, 3-6 parts of filler, 1-3 parts of dispersing agent and 1-2 parts of assistant. And the degree of functionality of the polyester acrylate oligomer is between 3 and 7. The higher the functionality of the polyester acrylic acid is, the stronger the reaction activity is, so that the curing speed can be improved, but the too high functionality can cause the increase of the viscosity and the reduction of the flexibility. The printing ink has the advantages of favorable toughness, appropriate drying speed, favorable filler wetting effect, favorable oleophylic-hydrophilic balance and favorable chroma resistance. Through the matching of the components and the manufacturing method, the weather-resistant printing ink has better weather resistance, the color difference change is smaller in different areas and different temperatures, and the distinguishing degree of printed matters is effectively improved.