The invention discloses a manufacturing process of a high-efficiency retarder, which comprises the following steps: 1) weighing an organosilicon modified acrylic emulsion, a film-forming agent, a water reducing agent and polyethylene glycol in parts by weight, and mixing them uniformly; 2) placing them in water Add amantadine ethylamine, phosphorous acid, sodium glucoheptonate, stir and heat to 60-80 ℃, and add formaldehyde solution dropwise; 3) after dissolving white sugar, add citric acid, tartaric acid, borax, maltodextrin, stir and mix. 4) Mix the slurry prepared in steps 1), 2), and 3) together, stir, and mix to obtain a retarder. The retarder of the invention has good retardation effect, stable chemical properties when applied to cement slurry, easy adjustment of thickening time, can avoid premature coagulation of cement, reduce the loss rate of cement strength, and has good Regularity and operability, low cost and simple operation.