The invention discloses an abrasion-resistant and anti-fouling film used for mouse touch board glass. The abrasion-resistant and anti-fouling film comprises, by weight, 80 parts to 120 parts of polyester resin, 60 parts to 80 parts of epoxy resin E-22, 30 parts to 60 parts of epoxy resin 601, 20 parts to 50 parts of zinc phosphate, 10 parts to 30 parts of aluminum triphosphate, 2 parts to 8 parts of sericite, 3 parts to 9 parts of nanometer kieselguhr, 2 parts to 8 parts of imvite, 1 part to 5 parts of silicon carbide, 3 parts to 5 parts of silica powder, 1 part to 5 parts of ceramic powder, 2 parts to 4 parts of white alundum powder, 1 part to 5 parts of adhesion promoters, 1 part to 5 parts of dispersing agents, 2 parts to 4 parts of flatting agents, 3 part to 5 parts of defoaming agents, 2 parts to 4 parts of chlorcosane, 1 part to 5 parts of titanium dioxide, 2 parts to 4 parts of carbon black, 1 part to 5 parts of polyamide 650, 2 parts to 4 parts of 2,4,6-tri(dimethylamino)mesitol and 2 parts to 6 parts of mixed solvents. The abrasion-resistant and anti-fouling film used for the mouse touch board glass has the excellent cohesiveness, the excellent abrasion resistance and the excellent anti-fouling performance.