The invention discloses a large-scale automotive intelligent comprehensive braking control system, which comprises an accelerator pedal sensor, a brake pedal sensor, an engine rotating speed sensor, a vehicle speed sensor, a braking pressure sensor, an exhaust braking control subsystem, a retarder control subsystem, and a main braking control subsystem. The system is characterized in that the exhaust braking control subsystem, the retarder control subsystem, and the main braking control subsystem are connected with an embedded central control computer through a bus; the accelerator pedal sensor, the brake pedal sensor, the engine rotating speed sensor, the vehicle speed sensor, and the braking pressure sensor are also connected with the embedded central control computer respectively, and an intelligent comprehensive control policy library used for calculating the starting opportunity and braking strength of the subsystems is arranged in the embedded central control computer. The system has the characteristics of realizing the linkage of main braking, exhaust braking and retarder braking, reducing braking energy consumption, and improving braking safety.