The invention relates to a method for manufacturing a relief sculpture three-dimensional artistic print, which mainly comprises the steps of material selecting and plate making, layout treatment, pattern affiliation, pattern carving, watercolor painting, coloring and protective layer coating, etc. The print manufactured in the method of the invention has the advantages that the picture has outstanding three-dimensional and layering sensation and excellent appreciation effect, can be easily kept and stored, is uneasily faded due to being affected with damp or damaged due to the wood-consuming of the insect, has long storage years, etc., and simultaneously solves the problems of uneasy storage, easy wetting and fading or damage due to the wood-consuming of the insect, quite limited keeping and storage years, flat painting without three-dimensional impression and bad appreciation effect existing in the existing art painting. According to requirements, the prints with various dimensions and specifications can be conveniently made to meet the requirements for the appreciation and collection by the people, various painters and collectors in the method of the invention.