8 results about "Cycloalternan" patented technology

Disclosed in the present invention are a PARP1 / CDK6 dual-target inhibitor, and a preparation method therefor and the use thereof. The PARP1 / CDK6 dual-target inhibitor is a compound having a structure represented by formula I, or a pharmaceutically acceptable salt or solvate thereof, wherein L is selected from or , and R is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, sulfhydryl, cyano, nitro, methoxy, a C1-C8 alkyl, or a C3-C8 cycloalkyl. The PARP1 / CDK6 dual-target inhibitor of the present invention exhibits good effects against human breast cancer cells, and maintains a good in vitro enzyme inhibitory activity against CDK6 and PARP1. Disclosed in the present invention is the use of a CDK6 / BRD4 dual-target inhibitor in the preparation of a drug for treating PARP1 / CDK6-mediated diseases. Disclosed in the present invention is the use of a PARP1 / CDK6 dual-target inhibitor in the preparation of a drug for treating or preventing triple-negative breast cancer.

This invention discloses a method for constructing a macromolecular model of Hami oil-rich coal and its application. The molecular formula and functional group characteristics of the coal sample are determined through elemental analysis and infrared spectroscopy. A planar structural model is constructed using the Wiser model framework, and a stable configuration is obtained after geometric optimization. Finally, a pyrolysis reaction model containing multiple molecules is constructed through stacking. Targeting the high-oxygen and high-cycloalkane structural characteristics of Hami oil-rich coal, a C1... 128 H 82 NO 16 and C 111 H 88 NO 28 Two precise models were used, and the accuracy of the calculated infrared spectra was verified by comparing them with experimental spectra. ReaxFF molecular dynamics simulations were performed using this model, revealing the influence of different heating rates and pyrolysis temperatures on product distribution. The optimal simulation temperature and critical values ​​for pyrolysis rate control were determined, and the difference in ethylene formation pathways between alkyl-rich coal and ether-rich coal was analyzed. This invention fills the gap in precise models for Hami oil-rich coal, providing key theoretical basis and parameter guidance for optimizing pyrolysis processes, achieving targeted regulation, and improving energy efficiency.

This invention relates to novel 2-(1-hydroxypentyl)benzoate, its preparation method, and its applications. Specifically, it relates to a cycloalkanamine 2-(1-hydroxypentyl)benzoate with the structure shown in Formula I, its preparation method, pharmaceutical compositions with the compound as the active ingredient, and the application of the compound in the treatment and / or prevention of ischemic cardiovascular and cerebrovascular diseases, especially mild, moderate, and severe acute ischemic stroke.

This invention provides compounds of general formula (I) or pharmaceutically acceptable salts, precursors, solvates thereof, and their use in the preparation of diagnostic drugs for diabetic nephropathy, wherein (I) X is selected from carbon or nitrogen; R 1 Selected from hydrogen or alkyl; R 2 It is one or more substituents on the benzene ring or pyridine ring, R 2 Independently selected from one or more of hydrogen, halogen, hydroxyl, cyano, nitro, amino, C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkoxy, C3-C6 cycloalkoxy, C1-C6 alkylamino, C3-C6 cycloalkylamino, halo-C1-C6 alkyl, halo-C3-C6 cycloalkyl, halo-C1-C6 alkoxy, halo-C3-C6 cycloalkoxy, halo-C1-C6 alkylamino, halo-C3-C6 cycloalkylamino, C6-C8 aryl or C5-C8 heteroaryl, and R 2 At least one atom of these substituents, or the entire substituent, is replaced by a radioactive nuclide. The diagnostic drugs and methods for diabetic nephropathy of the present invention are non-invasive diagnostic techniques, with advantages such as less discomfort for the subjects and fewer contraindications.

This invention belongs to the field of chemical medicine, specifically relating to a phenylpropanoid compound, its preparation method, and its application. The phenylpropanoid compound specifically refers to the compound, solvate, optically pure isomer, stereoisomer, or pharmaceutically acceptable salt thereof, or mixtures thereof, represented by general formula (Ⅰ), wherein X is selected from O or N; R1, R2, R3, R4, and R5 are the same or different, and are independently selected from hydrogen, hydroxyl, halogen, alkoxy, and alkylthio groups; R 13 Selected from hydrogen or C1-C4 alkyl, or R 13 Connect R5 to form a loop; R 14 The compounds are selected from cycloalkyl groups with 5-6 substituted carbon atoms. The phenylpropanoid compounds synthesized in this invention exhibit significant inhibitory effects on glioma cells, and their inhibitory effect is superior to that of the positive control drugs temozolomide and the original chlorogenic acid. Simultaneously, some of the synthesized phenylpropanoid compounds significantly improve neuronal cell survival rates, and their protective effect is superior to that of the positive control drug edaravone, demonstrating potential for treating stroke.

The application belongs to the field of mechanical color-changing materials, and relates to a tetraphenyl ethylene-containing cycloalkane and a preparation method thereof, and a mechanical response luminescent polymer based on AIE supramolecular cycloalkane and application. The structure of the tetraphenyl ethylene-containing cycloalkane is shown in formula I: in formula I, A is a tetraphenyl ethylene structural unit, m is an integer of 2-20, and n is an integer of 2-20. In the application, AIEgens is designed as a cycloalkane, and the mechanical force only changes the conformation of the ring, that is, only the intramolecular interaction is changed so as to change the luminescent intensity of the molecule. The luminescent characteristics are independent of the AIEgens concentration and the morphology of the material. The mechanical response luminescent polymer based on AIE supramolecular cycloalkane has stronger applicability.

This invention discloses a broad-spectrum antibacterial agent based on azide compounds and its application in the control of soil-borne agricultural diseases, belonging to the field of agricultural biotechnology. The antibacterial agent contains azide compounds with the general formula R1-AZ (AZ being an azide group, and R1 selected from specific substituents such as alkyl and cycloalkyl groups), specifically including various compounds such as phosphate esters, alkyl and cycloalkyl groups, carbonate / ether / alcohol groups, etc., which can be obtained through isolation from secondary metabolites of *Fusarium graminearum* or chemical synthesis. It exhibits significant inhibitory activity against various difficult-to-control soil-borne pathogens such as *Fusarium oxysporum* and *Blastomyces oryzae*, completely inhibiting the growth of target strains at concentrations of 30-100 ppm, and also showing good control efficacy in field trials. This invention solves the problems of strong resistance to existing chemical pesticides and unstable biological control effects, providing a new, efficient, and environmentally friendly solution for the control of agricultural diseases.