The invention discloses a method for treating a deep soft soil foundation by combining a chemical electro-osmosis method and a vacuum preloading method. In the method, vertical porous drain pipes and metal electrodes are inserted and chemical solution is injected into the soft soil foundation, horizontal drain boards and seal geomembranes are laid on the top of a soil layer, direct current is supplied, vacuumization is carried out, and under the action of direct-current electric field force, water with positive charge and cation solution flow to a cathode and anion solution with negative charge flows to an anode to form electro-osmosis and chemical reaction; meanwhile, under the action of internal and external pressure difference formed through vacuumization, water is quickly discharged from the drain pipe in which the cathode is positioned; and the solidification and compactness of the foundation soil are accelerated and the soil strength of the soil is improved. Compared with the common vacuum preloading method, the method has the advantages that: the soft soil treatment depth is increased, the deep layer of the soil of which the vacuum degree is difficult to reduced can be reached, and under the action of the direct-current electric field force, the solidification rate of the soil is improved and the construction period is shortened. Through the method, the construction process is simple, the operability is high, the construction period is short, the quality control and detection are facilitated, and the soil strength is improved obviously.