The invention provides a process for resin sand full mold casting. The process comprises the following steps: manufacturing a model by a foam materiel; coating paint on the surface of the model, and drying the model; modeling, namely, putting the dried model into a sand box, laying a pouring channel, filling resin sand into the sand box to model, and providing a shrink head on the model; and pouring, sand shaking and cleaning, namely, pouring molten iron into the sand box, opening the box to shake sand after the molten iron is cooled, and cleaning the cast, wherein during pouring, the sand box keeps a vacuum state. According to the process for the resin sand full mold casting, because the sand box keeps the vacuum state during pouring, large amount of waste gas and smoke generated by the foam model can be taken away by a vacuum system and subjected to uniform treatment, so that the waste gas and the smoke are not discharged into a workshop and can not cause pollution; and because the waste gas is taken away by the vacuum system in time, the molten iron can be filled smoothly, so as to avoid casting defects that filling is not full, air holes are generated, and the like.