Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

34 results about "P-hydroxyphenylglycine methyl ester" patented technology

L-p-Hydroxyphenylglycine methyl ester hydrochloride 97% Synonym: (S)-Amino-(4-hydroxyphenyl) acetic acid methyl ester hydrochloride CAS Number 127369-30-6. Empirical Formula (Hill Notation) C 9 H 11 NO 3 · HCl . Molecular Weight 217.65 . MDL number MFCD01862153

Improved method for preparing amoxicillin by enzymic method

The invention relates to the field of pharmacy, and provides an improved method for preparing amoxicillin by an enzymic method, and a product obtained by the improved method for preparing amoxicillin by the enzymic method. The method comprises the following steps of: 1) dissolving 6-aminopenicillanic acid (6-APA) at the temperature of between 10 and 20 DEG C by using water or/and aqueous solution of ammonia which has the pH value of 7.0 to 8.0, and adding D-p-Hydroxyphenylglycine methyl ester hydrochlorid and penicillin G acyltransferase; 2) adjusting the pH value of a solution obtained in the step 1) to be 6.0 to 6.5, and reacting at the temperature of between 21 and 30 DEG C until the content of 6-APA is less than 5mg/ml to obtain a solution of an amoxicillin product; and 3) separating the penicillin G acyltransferase from the solution of the amoxicillin product, adjusting by using hydrochloric acid until the solution of the amoxicillin product is clarified, adding the aqueous solution of ammonia, adjusting the pH value to be 5.5 to 6.5, and crystallizing at the temperature of between 0 and 5 DEG C to obtain amoxicillin. By the improved method for preparing amoxicillin by the enzymic method, the quality of the amoxicillin product is greatly improved, and the medication safety of the amoxicillin product is further improved.
Owner:UNITED LAB INNER MONGOLIA CO LTD

Method for comprehensively recovering effective ingredients in amoxicillin mother liquid prepared by enzyme process

The invention relates to a method for comprehensively recovering effective ingredients in amoxicillin mother liquid prepared by an enzyme process. The method comprises the following steps: (1) concentrating the amoxicillin mother liquid, namely adjusting the pH value of the amoxicillin mother liquid prepared by the enzyme process to be 8.0-9.5, and performing nanofiltration and concentration to obtain concentrated mother liquid; (2) synthesizing amoxicillin under enzyme catalysis, namely adjusting the pH value of the concentrated mother liquid to be 5.8-7.0, and converting 6-APA (6-amino penicillanic acid) and D-methyl hydroxyphenyl glycinate into amoxicillin in the presence of immobilized penicillin acylase for synthesis; (3) preparing D-hydroxyphenyl glycine concentrated liquid by ultrafiltration and nanofiltration, namely separating after the enzyme catalysis reaction is ended to obtain amoxicillin crystals and secondary amoxicillin mother liquid, and performing ultrafiltration and nanofiltration on the secondary mother liquid to obtain the D-hydroxyphenyl glycine concentrated liquid; (4) crystallizing D-hydroxyphenyl glycine. According to the method, 6-APA and D-methyl hydroxyphenyl glycinate remained in the mother liquid are consumed through an indirect process of synthesizing amoxicillin under enzyme catalysis, the product quality of D-hydroxyphenyl glycine is improved, and the yield of D-hydroxyphenyl glycine is increased.
Owner:SHANXI WEIQIDA PHARMA IND

Preparation method of D-para hydroxybenzene glycine methyl ester

The invention provides a preparation method of D-para hydroxybenzene glycine methyl ester. The method comprises the following steps of: firstly, preparing a hydrochloric acid methanol solution; adding D-para hydroxybenzene glycine into the hydrochloric acid methanol solution to perform reflux reaction for 2-4 hours at 65-80 DEG C; performing pressure reduction distillation and removing methanol; and adding water to obtain a D-para hydroxybenzene glycine methyl ester aqueous solution. Based on that, the invention also provides anenzymatic synthesis method of amoxicillin. The method comprises the following steps of: adding 6-APA and immobilized penicillin acylase into the D-para hydroxybenzene glycine methyl ester aqueous solution to react for 1-8 hours at 10-30 DEG C; regulating the pH value of a reaction liquid to 0.8-1.0 by using hydrochloric acid or sulfuric acid aqueous solution; regulating the pH value to 4.5-6.0 by using ammonia water or sodium hydroxide aqueous solution to crystallize for 1-5 hours at 0-30 DEG C; separating solid from liquid; collecting a solid; and washing and drying to obtain amoxicillin. The method is simple in steps, and low in cost; and the obtained -para hydroxybenzene glycine methyl ester is high in yield and less in impurities and can be directly applied to anenzymatic synthesis of amoxicillin.
Owner:NORTH CHINA PHARM GRP SEMISYNTECH CO LTD

Process for direct preparation of amoxicillin by liquid 6-APA (amino penicillanic acid)

The invention belongs to the technical field of medicine preparation and relates to a process for direct preparation of amoxicillin by liquid 6-APA (amino penicillanic acid). The process includes: taking penicillin degreasing solution as an initial material, sequentially performing cracking reaction, extraction, phase splitting, resin column adsorptive purification, distillation and concentration to obtain a 6-APA solution with the concentration being 80-100g/L, and synthesizing with p-hydroxyphenylglycine methyl ester under a catalytic action of type-II penicillin G acylase to obtain the amoxicillin. Compared with a traditional method, the process has the advantages that subsequent steps of 6-APA crystallization, centrifuging, drying and the like are avoided, investment of fixed assets is reduced, energy loss, equipment loss and cost are reduced, profits are increased, and physical injuries of staffs are reduced. Compared with existing direct amoxicillin preparation methods, the process has the advantages that by adoption of dichloromethane as an extracting agent, total mole yield of amoxicillin is higher relatively, the extracting agent is easy for distillation separation, the content of residual solvents in products is greatly reduced, medication safety is improved, and the process is worthy of popularization in production.
Owner:INNER MONGOLIA CHANGSHENG PHARMA

Method for synthesizing D-p-hydroxyphenylglycine methyl ester

The invention relates to the field of compound synthesis and discloses a method for synthesizing D-p-hydroxyphenylglycine methyl ester. The method comprises steps as follows: (1), in the presence of thionyl chloride, D-p-hydroxyphenylglycine resolving agent salt and methanol have an esterification reaction, and D-p-hydroxyphenylglycine methyl ester resolving agent salt is obtained; (2), the D-p-hydroxyphenylglycine methyl ester resolving agent salt and alkaline metal hydroxide are dropwise added to a D-p-hydroxyphenylglycine methyl ester aqueous solution at the temperature of 10-15 DEG C, the pH (potential of hydrogen) value of a system is controlled in the range from 6.5 to 7 in the dropwise adding process, after dropwise adding of the D-p-hydroxyphenylglycine methyl ester resolving agent salt is completed, alkaline metal hydroxide is continuously dropwise added until the pH value of the system ranges from 7.5 to 8, a crystal is grown at the temperature of 10-15 DEG C and under the condition of the pH value being 7.5-8, an obtained crystalline liquid is filtered, and a D-p-hydroxyphenylglycine methyl ester crystal and a mother liquor are obtained. With adoption of the method provided by the invention, D-p-hydroxyphenylglycine methyl ester with a higher yield can be produced.
Owner:山西双雁生物科技有限公司

A method for synthesizing d-p-hydroxyphenylglycine methyl ester

The present invention relates to the field of compound synthesis and discloses a method for synthesizing D-para-hydroxyphenylglycine methyl ester. The method comprises the steps of: (1) in the presence of thionyl chloride, carrying out an esterification reaction of D-para-hydroxyphenylglycine resolving agent salt and methanol to obtain a D-para-hydroxyphenylglycine methyl ester resolving agent salt; (2) dropwise adding the D-para-hydroxyphenylglycine methyl ester resolving agent salt and an alkaline metal hydroxide to an aqueous D-para-hydroxyphenylglycine methyl ester solution at 10-15°C, controlling the pH value of the system at 6.5-7 during the dropwise addition, after completing the dropwise addition of the D-para-hydroxyphenylglycine methyl ester resolving agent salt, continuing the dropwise addition of the alkaline metal hydroxide until the pH value of the system is 7.5-8, then growing crystals under the conditions of a temperature of 10-15°C and the pH value of 7.5-8, and subsequently filtering the resultant crystallization liquid to obtain D-para-hydroxyphenylglycine methyl ester crystals and a mother liquor. With the adoption of the method provided by the present invention, D-para-hydroxyphenylglycine methyl ester can be produced with a higher yield.
Owner:山西双雁生物科技有限公司

Method for Comprehensive Recovery of Active Components in Enzymatic Amoxicillin Mother Liquor

The invention relates to a method for comprehensively recovering effective ingredients in amoxicillin mother liquid prepared by an enzyme process. The method comprises the following steps: (1) concentrating the amoxicillin mother liquid, namely adjusting the pH value of the amoxicillin mother liquid prepared by the enzyme process to be 8.0-9.5, and performing nanofiltration and concentration to obtain concentrated mother liquid; (2) synthesizing amoxicillin under enzyme catalysis, namely adjusting the pH value of the concentrated mother liquid to be 5.8-7.0, and converting 6-APA (6-amino penicillanic acid) and D-methyl hydroxyphenyl glycinate into amoxicillin in the presence of immobilized penicillin acylase for synthesis; (3) preparing D-hydroxyphenyl glycine concentrated liquid by ultrafiltration and nanofiltration, namely separating after the enzyme catalysis reaction is ended to obtain amoxicillin crystals and secondary amoxicillin mother liquid, and performing ultrafiltration and nanofiltration on the secondary mother liquid to obtain the D-hydroxyphenyl glycine concentrated liquid; (4) crystallizing D-hydroxyphenyl glycine. According to the method, 6-APA and D-methyl hydroxyphenyl glycinate remained in the mother liquid are consumed through an indirect process of synthesizing amoxicillin under enzyme catalysis, the product quality of D-hydroxyphenyl glycine is improved, and the yield of D-hydroxyphenyl glycine is increased.
Owner:SHANXI WEIQIDA PHARMA IND

Synthetic method of amoxicillin production intermediate

The invention relates to a synthesis method of an amoxicillin production intermediate, which comprises the following steps of: synthesizing D-p-hydroxyphenylglycine methyl ester by taking DL-p-hydroxyphenylglycine and methanol as raw materials and solid phosphoric acid as a catalyst; comprising the following five parts: preparation of a solid phosphoric acid catalyst, preparation of DL-p-hydroxyphenylglycine methyl ester, hydrolysis of the solid phosphoric acid catalyst, crystallization of D-p-hydroxyphenylglycine methyl ester and racemization of crystallization mother liquor. The solid phosphoric acid catalyst can be hydrolyzed into phosphoric acid after esterification is completed, phosphoric acid and DL-p-hydroxyphenylglycine methyl ester form phosphoric acid double salt, and phosphoric acid serves as an esterification catalyst for synthesis of DL-p-hydroxyphenylglycine methyl ester and also serves as a resolving agent of DL-p-hydroxyphenylglycine methyl ester. The synthesis and resolution of the DL-p-hydroxyphenylglycine methyl ester are carried out in the methanol aqueous solution, and the crystallization mother liquor is recycled, so that the generation of waste liquid is greatly reduced, and the method is a clean production process of the D-p-hydroxyphenylglycine methyl ester.
Owner:TIANJIN HANRUI PHARMA +1

Method for preparing amoxicillin or ampicillin through full water phase

ActiveCN105132513BHigh vitality coefficientEasy to synthesizeFermentationPenicillin VKHigh concentration
The invention discloses a method for preparing amoxicillin or ampicillin in a full-water-phase through mode. The method includes the steps that a high-concentration penicillin GK or penicillin VK extracting solution is used as a raw material, immobilized penicillin G acylase or penicillin V acylase is used as an enzyme catalyst, a high-concentration 6-APA solution or crystal is obtained through full-water-phase operations such as catalytic cracking, separating, acidization, filtering, chromatography and concentration by nanofiltration, and then the amoxicillin or the ampicillin is synthesized by the solution or crystal and HPGME or phenylglycine methyl ester under the catalytic action of the immobilized penicillin synthetase. According to the method, water-phase reacting is conducted in the whole process, no organic solvent is used, and environmental pollution is reduced; besides, the special immobilized penicillin G acylase and the penicillin V acylase are used for cracking the high-concentration penicillin GK or VK extracting solution, and special macroporous absorption resin is used for separating and cracking products, so that the processing steps are greatly simplified, the production cost is lowered, the product yield is increased, and the industrial production requirement is met.
Owner:HUNAN FLAG BIOTECHNOLOGY CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products