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Jump to navigation Jump to search. Tobacco mosaic virus (TMV) is a positive-sense single stranded RNA virus, genus tobamovirus that infects a wide range of plants, especially tobacco and other members of the family Solanaceae.

Beta-amino acid esters having optical activity and containing benzothiazole groups and synthetic method and application thereof

InactiveCN101817803ABiocideOrganic chemistryThioureaSynthesis methods

The invention discloses a synthetic method and bioactivity of beta-amino acid esters which have optical activity and contain benzothiazole groups. The beta-amino acid esters which have optical activity and contain the benzothiazole groups have the structure shown in the general formula (I), and in the formula, R1 is a group of hydrogen, p-chloro, o-chloro, p-fluoro, o-fluoro, p-methyl, o-methoxy and the like; R2 is a group of 4-methyl, 6-methoxy and the like; and R3 is a group of methyl, ethyl, propyl, isopropyl and the like. The invention introduces Mannich reaction which uses organic catalyst of cinchona alkaloid thiourea to catalyze benzothiazole imine and malonate, the product is obtained by one-step synthesis, and the reaction yield and the selectivity to enantiomer are both high. Compounds c, d and e in the inveniton have high therapeutic and passivation inhibiting effects towards tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) and show good anti-plant virus activity.

Beta-amino acid esters having optical activity and containing benzothiazole groups and synthetic method and application thereof

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Owner:GUIZHOU UNIV

Metamaterial Optical Elements Self-Assembled on Protein Scaffolds

InactiveUS20130181171A1Polarising elementsMaterial analysis by optical meansEngineeringCoat Proteins

Protein scaffolds from tobacco mosaic virus coat protein modified to incorporate polyhistidine can bind to a metal or a dye while having improved self-assembly characteristics. The scaffold can take the form of tubes or disks, and can further be formed into dual plasmonic ring resonators. Such self-assembled structures provide useful optical properties.

Metamaterial Optical Elements Self-Assembled on Protein Scaffolds

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Owner:UNITED STATES OF AMERICA

Virus induced gene silencing system and use thereof

InactiveCN101418313AFermentationGenetic engineeringDNA fragmentationA-DNA

The invention relates to a virus-induced gene silencing system in particular using tobacco mosaic virus TMV as a vector. In the system, a DNA segment of a target gene is inserted between a termination codon and a 3' untranslated region of coat protein CP of the tobacco mosaic virus TMV; a polyclonal restricted endo enzyme cutting point is introduced between the termination codon and the 3' untranslated region of the coat protein CP of the tobacco mosaic virus TMV and is used for the insertion of the DNA segment of the target gene; and a section of a basic group sequence on the bottom end of CP3' is introduced in the front of the 3' untranslated region so as to strengthen the stability of the silencing vector. The DNA segment of the target gene is not more than 1 kb. The gene silencing system is utilized to carry out silencing on the target gene and is economic, feasible, convenient and effective.

Virus induced gene silencing system and use thereof

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Owner:SHANGHAI UNIV

Phenanthroindolizidine alkaloid glycosylation product, 6-site derivatization product, and preparation methods and plant virus resistance activities of phenanthroindolizidine alkaloid glycosylation product and 6-site derivatization product

ActiveCN103923134AEsterified saccharide compoundsBiocideSolubilityWater soluble

The present invention relates to a phenanthroindolizidine alkaloid glycosylation product, a 6-site derivatization product, and preparation methods and plant virus resistance activities of the phenanthroindolizidine alkaloid glycosylation product and the 6-site derivatization product, wherein various groups in the formula are defined in an instruction. According to the present invention, the phenanthroindolizidine alkaloid glycosylation product has characteristics of good light stability, good thermal stability, good water solubility and excellent plant virus resistance, and the glycosylation product and 6-site derivatization product can well inhibit tobacco mosaic virus (TMV). The formula I is as the follow.

Phenanthroindolizidine alkaloid glycosylation product, 6-site derivatization product, and preparation methods and plant virus resistance activities of phenanthroindolizidine alkaloid glycosylation product and 6-site derivatization product

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Owner:NANKAI UNIV

Poly-substituted miazines compound, preparation method and application thereof

InactiveCN101580493AStrong growth inhibitory effectBiocideOrganic chemistryStereochemistryTobacco mosaic virus TMV

The invention discloses a poly-substituted miazines compound having anti-plant virus activity, a preparation method and application thereof. The structure of the poly-substituted miazines compound is shown in formula (I). Experiments prove that the poly-substituted miazines compound has remarkable effect of growth inhibition to the tobacco mosaic virus, so that the compound can be made into antiviral agents with different concentrations and types according to the actual production and be applied to agricultural industry.

Poly-substituted miazines compound, preparation method and application thereof

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Owner:CHINA AGRI UNIV

Pyrazolyloxadiazole thioether compounds, and preparation method and application thereof

ActiveCN106496212ANovel structureStrong therapeutic activityBiocideOrganic chemistryPyrazoleThioether

The invention discloses a preparation method for pyrazolyloxadiazole thioether compounds and application of the pyrazolyloxadiazole thioether compounds to resisting of the activity of a tobacco mosaic virus (TMV). The compounds have a structure as shown in a general formula (I) which is described in the specification. According to the invention, on the basis of a 5-amino-1-(3-chloro-2-pyridyl)-4-(5-methylmercapto-1,3,4-oxadiazol-2-yl)pyrazol structure, a series of the pyrazolyloxadiazole thioether compounds with a novel structure are synthesized through substitution of an amino group at position 5. Results of testing of the protection and treatment activity of the compounds to the TMV show that the compounds have good treatment activity to viral diseases caused by the TMV and lay an important scientific foundation for research, development and creation of novel pesticides.

Pyrazolyloxadiazole thioether compounds, and preparation method and application thereof

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Owner:GUIZHOU UNIV

Bi-triazole compound, preparation method and application thereof

InactiveCN1687059AEasy to makeCheap manufacturingBiocideOrganic chemistryCyclohexeneAlkyne

The present invention relates to a triazole compound. Said invention provides its general formula. Its preparation method includes the following steps: using 5-triazo-1,2,4 triazol-3-acyl methyl ester and propiolic alcohol ester acetate, p-amyl phenylacetylene, syclohexanol alkyne, cyclohexene alkyne or methoxyphenyl acetylene, and making them be reacted in the tetrahydrofuran or mixed solvent of tetrahydrofuran and water at 10-100 deg.C under the action of Cu(I) catalyst so as to obtain the required triazole compound. Said triazole compound has the activity for directly inhibiting plant virus, in particular inhibiting tobacco mosaic virus.

Bi-triazole compound, preparation method and application thereof

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Owner:WUHAN UNIV

Method for using tobacco mosaic virus to overproduce peptides and proteins

InactiveUS20030208792A1Prone to infectionNanotechSsRNA viruses positive-senseNicotiana tabacumInclusion bodies

The invention describes compositions and methods of use in which an infectious modified Tobacco Mosaic Virus (TMV) virion comprising a coat protein (CP) or a movement protein (MP) gene is replaced with a nuclear inclusion protease (NIa) expression cassette for the expression of a heterologous peptide in a tobacco mosaic virus (TMV) host plant.

Method for using tobacco mosaic virus to overproduce peptides and proteins

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Owner:THE SCRIPPS RES INST

Microsensor controllable array preparation method using tobacco mosaic virus as template

InactiveCN108956983AEfficient access to raw materialsLow costMaterial analysisUnit sizeCysteine thiolate

The invention discloses a microsensor-controllable array preparation method using tobacco mosaic virus as a template. According to the method, a phage display technology is utilized to obtain a polypeptide molecule that binds to a specific functional nanoparticle; and a gene sequence corresponding to the polypeptide molecule is obtained by gene sequencing. Subsequently, the tobacco mosaic virus isgenetically modified by a molecular biological means, and the polypeptide molecule that binds to the specific functional nanoparticle is adsorbed on coat protein to bind to the specific functional nanoparticle to obtain sensitive units; and at the same time, cysteine (Cys) is introduced into substrate surface protein, by using a binding mechanism of the cysteine and gold (Au) nanoparticles, arraydistribution of the sensitive units of a sensor can be achieved. The method using the tobacco mosaic virus as the template to realize sensor controllable array can greatly reduce an array unit size,improves the resolution and sensitivity of the sensor, and can be applied to array design and preparation of pressure sensors and gas sensors.

Microsensor controllable array preparation method using tobacco mosaic virus as template

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Owner:NORTHWESTERN POLYTECHNICAL UNIV

Method for preparing tobacco mosaic virus capsid protein capsule

ActiveCN106822030AIncrease coverageEasy to prepareCapsule deliveryMacromolecular non-active ingredientsCross-linkProtein solution

The invention discloses a method for preparing a tobacco mosaic virus capsid protein capsule. The method comprises the following steps: preparing a tobacco mosaic virus capsid protein solution, mixing the tobacco mosaic virus capsid protein solution with an oil phase to form an emulsion, adjusting the pH value of the system to control the tobacco mosaic virus capsid protein to form a rod-shaped combined structure, and cross-linking the rod-shaped tobacco mosaic virus capsid protein at an oil-water boundary by using glutaraldehyde as a cross-linking agent, thereby obtaining the tobacco mosaic virus capsid protein capsule. The method for preparing the tobacco mosaic virus capsid protein, which is disclosed by the invention, is simple in step, short in preparation cycle, high in surface wrapping rate of prepared protein capsules, and solid and uniform in capsule structure.

Method for preparing tobacco mosaic virus capsid protein capsule

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Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI

Metamaterial optical elements self-assembled on protein scaffolds

InactiveUS8831386B2Material analysis by optical meansPolarising elementsEngineeringCoat Proteins

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Owner:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

Chirality oliopeptide phosphonate thiourea derivatives and application and preparation method thereof

InactiveCN105601703AEnhanced inhibitory effectEasy to useBiocidePeptidesThioureaInhibitory effect

The invention provides chirality oliopeptide phosphonate thiourea derivatives and application and a preparation method thereof. A series of chirality oliopeptide phosphonate thiourea derivatives of novel structures are designed and synthesized. Each derivative comprises an amino acid skeleton, a thiourea-based functional group and an amino phosphonate component, and the molecular structure is provided with multiple chirality centers. Meanwhile, the compounds have a good inhibiting effect on plant viruses, and are suitable for preparing plant virus resistant agents and particularly suitable for new pesticide creation and research for tobacco mosaic viruses (TMV). The preparation method is good in reliability, good symmetry selectivity and high yield are achieved, and the material basis is provided for follow-up research. The material source is simple, and the material is easy to obtain, low in cost and good in use effect.

Chirality oliopeptide phosphonate thiourea derivatives and application and preparation method thereof

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Owner:GUIZHOU MEDICAL UNIV +1

1-phenyl-5-amino-4-pyrazole bi-oxadiazole thioether compounds and application thereof

ActiveCN107880033AThe passivation effect is remarkableGood treatment effectBiocideOrganic chemistryIn vivoThioether

The invention discloses a preparation method for 1-phenyl-5-amino-4-pyrazole bi-oxadiazole thioether compounds and an application in tobacco mosaic virus resistant activity. The compounds have structures represented by a general formula (I) in the description. The method provided by the invention is based on a 5-amino-1-(3-chloro-2-pyridyl)-4-(5-methylthio-1,3,4-oxadiazole-2-yl)-pyrazole structureand uses ''phenyl'' to replace ''3-chloro-2-pyridyl'' on the 1-position of a pyrazole ring to synthesize a series of the 1-phenyl-5-amino-4-pyrazole bi-oxadiazole thioether compounds, and experimentsof the compounds in vivo show that the compounds have good curative protective and inactivating activity on virus diseases caused by the tobacco mosaic virus (TMV), and the compounds show significanteffects on passivation effects compared with compounds reported in the earlier work of a research group; and the compounds provide an important scientific basis for the research, development, creation of novel pesticides.

1-phenyl-5-amino-4-pyrazole bi-oxadiazole thioether compounds and application thereof

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Owner:GUIZHOU UNIV

Kealiinine derivative, preparation thereof and application of the derivative in resisting plant viruses and germs

ActiveCN110483405ASuppress witheringGood against plant virusBiocideOrganic chemistryTobacco mosaic virusBotany

The invention relates to a Kealiinine derivative II, a preparation method thereof and an application of the derivative II in resisting plant viruses and germs. The Kealiinine derivative II shows especially excellent plant virus resisting activity, can well inhibit tobacco mosaic viruses (TMV), and also shows certain plant pathogenic germ resisting activity.

Kealiinine derivative, preparation thereof and application of the derivative in resisting plant viruses and germs

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Owner:NANKAI UNIV

Disporum cantoniense polysaccharide extracted by ultrasound-assisted enzymatic method and extraction method and application thereof

ActiveCN110950972APromote dissolutionHigh yieldOrganic active ingredientsBiocideUltrasonic assistedAlcohol

The invention discloses Disporum cantoniense polysaccharide extracted by an ultrasound-assisted enzymatic method and an extraction method and application thereof. The extraction method comprises taking 1 part by mass of Disporum cantoniense powder which is sieved by a 60-mesh sieve, soaking the Disporum cantoniense powder in 15-50 parts by mass of distilled water, adjusting the pH value to 3.5-7.0, standing the solution at the temperature of 30-70 DEG C for 15-30 minutes, then adding an enzyme which accounts for 0.1-10% of the mass of the dry powder of the Disporum cantoniense into the solution, carrying out enzymolysis at 30-70 DEG C for 0.5-3 hours to obtain a mixture, carrying out ultrasonic extraction at the temperature of 30-70 DEG C for 10-60 minutes, carrying out enzyme deactivationtreatment at the temperature of 80-90 DEG C for 5-20 minutes, carrying out cooling at the room temperature, centrifuging the mixture at the speed of 3000 to 6000 rpm for 10 to 30 minutes, concentrating the supernatant to 1 / 2-1 / 5 volume by using a rotary evaporator, then adding absolute ethyl alcohol of which the volume is 4-5 times that of the concentrated solution into the supernatant, standingthe solution at 4 DEG C for 2-8 hours, centrifuging the solution at the speed of 5000-6000 rpm for 10-20 minutes, washing the solution by using absolute ethyl alcohol, and freeze-drying the solution to obtain the product. The Disporum cantoniense polysaccharide has toxicity to tumor cells, has good inhibitory activity to tobacco mosaic viruses and cucumber mosaic viruses, and is high in extractionrate, short in extraction time, energy-saving and environment-friendly.

Disporum cantoniense polysaccharide extracted by ultrasound-assisted enzymatic method and extraction method and application thereof

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Owner:GUIZHOU UNIV

Chloroisobromine cyanuric acid mixing preparation capable of preventing and controlling tobacco mosaic virus, and applications thereof

InactiveCN107183051AAvoid pollutionAvoid Pesticide Residue ProblemsBiocideDisinfectantsTreatment effectPesticide residue

The present invention provides a chloroisobromine cyanuric acid mixing preparation capable of preventing and controlling tobacco mosaic virus, wherein the active components comprise, by weight, 10-40 parts of lemongrass essential oil, 20-50 parts of a fragrant eupatorium herb alcohol extract, 5-20 parts of camellia oil, and 10-40 parts of chloroisobromine cyanuric acid. According to the present invention, the active components comprise the lemongrass essential oil, the fragrant eupatorium herb alcohol extract, the camellia oil and the low environment toxicity chloroisobromine cyanuric acid, such that the obtained chloroisobromine cyanuric acid mixing preparation has advantages of low toxicity, no pollution and no residue, is the environmentally friendly product, can avoid the problems such as environmental pollution and pesticide residues in agricultural production, and can provide significant passivation, prevention and treatment effects for tobacco mosaic virus.

Chloroisobromine cyanuric acid mixing preparation capable of preventing and controlling tobacco mosaic virus, and applications thereof

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Owner:海南江河农药化工厂有限公司

Bi-triazole compound, preparation method and application thereof

InactiveCN100334084CEasy to makeCheap manufacturingBiocideOrganic chemistryCyclohexeneAcyl group

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Owner:WUHAN UNIV

Application of nortopsentin alkaloids and derivatives thereof to prevention and treatment of plant diseases and insect pests

ActiveCN109418267ASuppress witheringHigh activityBiocideOrganic chemistryInsect pestPlant disease

The invention relates to the application of nortopsentin alkaloids and derivatives I thereof to resisting of plant viruses and pathogens and killing of insects. The nortopsentin alkaloids and the derivatives I thereof in the invention show particularly excellent activity against plant viruses, can effectively inhibit tobacco mosaic viruses (TMV), and also present excellent activity against plant pathogens and insecticidal activity. Substituents in a general formula as shown in the specification are defined in the specification.

Application of nortopsentin alkaloids and derivatives thereof to prevention and treatment of plant diseases and insect pests

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Owner:NANKAI UNIV

Primers and kit for detecting tobacco mosaic viruses RT-LAMP

InactiveCN108998571AQuick checkHigh detection sensitivityMicrobiological testing/measurementMicroorganism based processesPositive controlFluorescence

The invention discloses primers and kit for detecting tobacco mosaic viruses RT-LAMP. The kit comprises 0.5 milliliters of a RT-LAMP reaction solution buffer, 100 micro-liters of the primers, 60 micro-liters of a fluorescent dye, 60 micro-liters of an enzyme solution, 60 micro-liters of a positive control and 100 milliliters of deionized water. The primers for detecting tobacco mosaic viruses RT-LAMP solve the problems of the existing primers. The kit contains the primers and has the characteristics of rapid detection, high detection sensitivity, simple operation and direct reading of the result.

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Owner:陈定虎

Meridianin derivative as well as preparation and application thereof in prevention and treatment of plant virus and bacterial diseases

ActiveCN110759892ASuppress witheringGood against plant virusBiocideOrganic chemistryBiotechnologyBacterial disease

The invention relates to a meridianin derivative I as well as a preparation method and application thereof in prevention and treatment of plant virus and bacterial diseases. The meridianin derivativeI disclosed by the invention shows especially excellent plant virus resisting activity, can well inhibit tobacco mosaic virus (TMV), and also shows certain plant pathogenic bacterium resisting activity.

Meridianin derivative as well as preparation and application thereof in prevention and treatment of plant virus and bacterial diseases

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Owner:NANKAI UNIV

Application of tobacco mosaic virus in stimulation of polarization of macrophages into M1 type macrophages

PendingCN114480280AAvoid the risk of infectionCulture processBlood/immune system cellsImmunotherapyVirology

The invention discloses application of tobacco mosaic virus in stimulation of polarization of macrophages into M1 type macrophages. In the application, the tobacco mosaic virus can promote polarization of macrophages to M1 type, so that the macrophages have a killing effect, and a treatment scheme is provided for tumor immunotherapy.