The invention discloses a nano-zinc oxide protection introduced packaging material and a preparation method thereof, and the packaging material comprises a nano-zinc oxide resin layer, a titanium dioxide resin layer and a substrate. The preparation method mainly comprises the following steps: (1) uniformly mixing fluorocarbon, acrylic resin, isocyanate, propylene glycol methyl ether acetate (PGMEA), first color paste containing titanium dioxide, a dispersing agent, epoxy resin, a flatting agent, a catalyst and a solvent, coating a PET film with the mixture, and drying; and (2) uniformly mixing fluorocarbon, acrylic resin, isocyanate, PGMEA, second color paste containing nano-zinc oxide, a dispersing agent, epoxy resin, a flatting agent, a catalyst and a solvent, uniformly coating the film coating obtained in the step (1) with the mixture, and drying to obtain the packaging material introducing nano-zinc oxide protection. The introduced nano zinc oxide absorbs high-energy ultraviolet rays to protect the titanium dioxide in the inner layer, and in addition, due to the addition of the anti-reflection resin, the transmittance of the film to light of other wave bands is increased, and the light utilization rate is improved.