The invention relates to a comfortable and natural type OPTIM fiber, pima cotton, real silk and cashmere mixture knitting yarn knitted fabric structure. The structure comprises a basic stitch and a lace stitch. The lace stitch comprises a plurality of independent units. Each independent unit comprises six transverse columns A, B, C, D, E and F and fifteen longitudinal columns, wherein each transverse column corresponds to one piece of yarn; the transverse columns A, B, E and F each comprise fifteen coils, the transverse column C comprises thirteen coils, and the transverse column D comprises eleven coils. The structure is simple, and the manufactured comfortable natural type OPTIM fiber, pima cotton, real silk and cashmere mixture knitting yarn knitted fabric has the advantages of being hydrophilic, soft, smooth, breathable, thin, light, fluffy, capable of achieving heat preservation, glossy, gentle and the like, and has the functions of being durable, resistant to static electricity, resistant to pilling, resistant to fouling and the like.