The invention relates to a preparation method of a large-sized magnesium alloy forged disc and belongs to the technical field of magnesium alloy materialmachining. The preparation method of the large-sized magnesium alloy forged disc comprises the following steps of heating a casting magnesium alloy ingot to 400-430 DEG C and preserving the heat, wherein the casting magnesium alloy ingot after homogenizing thermal treatment is 300-350mm in diameter and 1.5-1.85 in height-diameter ratio; upsetting and drawing out the heated casting magnesium alloy ingot at 400-430 DEG C to obtain a magnesium alloy forged disc; repeating processes of heating, preserving the heat, upsetting and drawing out till the diameter of the magnesium alloy forged disc is larger than or equal to 670mm to obtain the large-sized magnesium alloy forged disc, wherein the temperature when repeating the procedures of preserving the heat and upsetting every time is 10-20 DEG C lower than the temperature when previously repeating the procedures of preserving the heat and upsetting, the forging ratio in each upsetting procedure is 1.5-2, the forging ratio in each drawing-out procedure is 1.02-1.05, and the deformation speeds in the upsetting and drawing-out procedures both are 12-16mm / s. According to the preparation method of the large-sized magnesium alloy forged disc, which is disclosed by the invention, the large-sized magnesium alloy forged disc with the diameter of 670-720mm, the thickness of 80-120mm, the tensile strength of larger than or equal to 300MPa, the yield strength of larger than or equal to 180Mpa and the elongation percentage of larger than or equal to 10% can be manufactured, and the manufactured large-sized magnesium alloy forged disc can completely meet the requirements on the preparation of a large-sized magnesium alloy die forged piece.