The invention relates to the technical field of packaging bag processing, and discloses a production and processing technology of a paper-plastic packaging bag. The production and processing technology needs to use a compounding device, and comprises the following steps that (1) material preparation is performed; (2) blow molding is performed, wherein plastic raw materials are added into a blow molding machine for blow molding to prepare a thin film, namely, a plastic layer; (3) printing is performed; (4) compounding is performed, wherein the plastic layer obtained after printing is compounded on raw-material paper through the compounding device, an adhesive of a glue coating roller is scraped through a scraper, the glue coating roller is used for perform glue coating on the raw-materialpaper, and then the plastic layer is pressed on the raw-material paper through a hot pressing roller for compounding to obtain a composite paper-plastic layer; (5) bag making is performed, wherein thecomposite paper-plastic layer firstly undergoes heat-seal edge sealing treatment, and then cold pressing shaping is performed on the sealed edge; and (6) slitting is performed, wherein the compositepaper-plastic layer is cut along the sealed edge to obtain the single paper-plastic packaging bag. According to the production and processing technology, the problem that in the prior art, glue coating is not uniform, and long-term use is performed, so that the adhesive becomes hard, and then the compounding effect is relatively poor can be solved.