The invention relates to a povidone iodine five-compound disinfectant which comprises the following components in percentage by weight: 5-20 percent of povidone lodine, 0.1-10 percent of medical glycerin, 0.1-2 percent of citric acid, 0.1-1 percent of nonoxynol-10, 0.01-0.1 percent of sodium hydroxide and the balance of water for injection. The povidone iodine five-compound disinfectant can be used for producing povidone iodine compound wipes with different specifications, povidone iodine compound cotton swabs, povidone iodine compound spongy cushions, povidone iodine compound hand-washing brushes and the like; and after the products are specially treated or sterilized, the sterility and the safety of the products are fully ensured, and after being unpacked, the products can be directly used, so that the cross contamination and the infection in an intermediate link are avoided. The povidone iodine five-compound disinfectant has the advantages of small skin irritation, low toxicity, lasting action, and safety and convenience in use; the povidone lodine five-compound disinfectant basically has no irritation to tissues and is used for skin and mucosa disinfection, such as cleaning before operation, operative site and wound disinfection, and skin cleaning and disinfection before and after arterial blood drawing.