The invention discloses an organic solar cell with MXene as an anode modification layer material and a manufacturing method thereof. An organic solar cell device includes an anode substrate, an anodemodification layer, an active layer, a cathode modification layer, and a cathode layer. The MXene with high conductivity, high transmission of light, and a work function matching with ITO is taken asthe anode modification layer material to manufacture the organic solar cell device. Firstly, the MXene has the high conductivity so that the charge transfer efficiency of the organic solar cell can beeffectively increased; secondly, the MXene can effectively adjust and control the work function, and reduce an interfacial ability between an anode and an active layer; and finally, compared with a corresponding PEDOT: PSS device, by using the cell and the method, higher photoelectric conversion efficiency is achieved.