The invention discloses a wire holding and bending setter, which comprises an operation platform, a fixed bracket, a right groove, a left groove, holding and moving wheels, a top groove, a top moving wheel, a setting wheel, an air cylinder and a control switch, wherein the fixed bracket is arranged at the inner side of one edge of the upper part of the operation platform; a concave arc wire protection surface is arranged at the inner side of the fixed bracket; the longitudinal top groove is arranged in the center of the inner side of the fixed bracket; a top moving arm is arranged at the lower of the top groove and is sequentially provided with the top moving wheel and the setting wheel; transverse left groove and right groove are formed in the left side and the right side, close to the fixed bracket, of the top groove respectively; a left moving arm and a right moving arm are arranged at the lower parts of the left groove and the right groove respectively; the holding and moving wheels are arranged on the left moving arm and the right moving arm respectively; the air cylinder provides the left moving arm, the right moving arm and the top moving arm with power; and the moving arms are controlled to move through the control switch. The wire holding and bending setter is simple in operation and high in work efficiency, and can be quickly completed by one person at present from 2-3 persons in the past, and the process quality of a product is good through perfect cooperation of the holding and moving wheels, the top moving wheel and the setting wheel.