The invention discloses workpiece paint spraying protection equipment adopting a gliding flow guide principle. The structure of the workpiece paint spraying protection equipment adopting the gliding flow guide principle comprises a controller, a main machine, a cooling groove, a fixing frame, a piece supporting mechanism, a paint spraying bin and pigment tanks. The main machine is of a rectangularstructure and installed at the right end of the fixing frame in an embedded manner. The top end of the fixing frame is provided with the paint spraying bin. According to the workpiece paint sprayingprotection equipment adopting the gliding flow guide principle, in the process of pulling out the workpiece supporting mechanism, the top of the workpiece supporting mechanism drives a pressurizing mechanism to conduct air pressure control in a sealed bin, so that the harmful gas suction speed of a flow guide assembly is increased, the bottom of the workpiece supporting mechanism drives a suctionmechanism in the flow guide assembly to synchronously move, the bottom of the suction mechanism generates rotation in the process of cooperating with inclined-face top seats, harmful gas is sucked through a reverse fan, and the harmful gas is discharged through two exhaust cylinders finally; and in this way, it is ensured that internal harmful gas is rapidly sucked within the process of pulling out the workpiece supporting mechanism, it is avoided that the harmful gas spreads outward and makes contact with workers, and threat to the life health is avoided.