This invention relates to the field of microbial
fermentation technology, and particularly to a co-culture
fermentation broth of medicinal and edible fungi with whitening effects, its preparation method, and its application. The preparation method of the co-culture
fermentation broth of medicinal and edible fungi with whitening effects includes: inoculating the seed liquid of a first
fungus and the seed liquid of a second
fungus into a co-fermentation medium for fermentation and co-culture to obtain the co-culture
fermentation broth of medicinal and edible fungi with whitening effects; the first
fungus includes at least one of *
Ganoderma lucidum* strain, *
Trametes versicolor* strain, *Poria cocos* strain, *
Auricularia auricula-judae* strain, *
Phellinus linteus* strain, and *
Aspergillus schavar*; the second fungus includes *
Schizophyllum commune*. This invention co-cultures *
Schizophyllum commune* with other specific strains and found that co-culturing the two strains can exert a synergistic effect, thereby significantly improving the
tyrosinase inhibition effect of the
fermentation broth. The
optimal combination of
fermentation broth can achieve a
tyrosinase inhibition rate of over 90%, and even 1 wt% of the fermentation broth has a
tyrosinase inhibition effect of approximately 90%.