The invention discloses an OCA optical adhesive, a preparation method and application of the OCA optical adhesive. The OCA optical adhesive comprises 2-ethylhexyl acrylate, isobornyl acrylate, 2-hydroxyethyl acrylate, 1-hydroxycyclohexyl benzophenone and a molecular weight control agent dodecanethiol. The preparation method of the OCA optical adhesive comprises the following steps of 1, mixing 2-ethylhexyl acrylate, isobornyl acrylate, 2-hydroxyethyl acrylate, 1-hydroxycyclohexyl benzophenone and dodecanethiol to obtain a monomer prepolymer, 2, exposing the monomer prepolymer to ultraviolet radiation in a nitrogen protection environment, and adding a photoinitiator and a cross-linking agent to obtain an OCA optical adhesive. The application of the OCA optical adhesive comprises the following steps of A, unwinding a release film, B, coating the release film with OCA optical adhesive to obtain the release film coated with the OCA optical adhesive, C, curing the release film coated with the OCA optical adhesive under illumination to obtain a cured optical adhesive film, and D, winding the cured optical adhesive film.