The invention belongs to the technical field of automobile antifreeze cooling liquids, and particularly relates to a synthetic additive type long-acting antifreeze cooling liquid, which comprises thefollowing components in parts by weight: 42-76 parts of ethylene glycol, 8-15 parts of glycerol, 3-10 parts of an organic composite additive, 2-4 parts of triethanolamine, 0.01-0.03 part of sodium benzoate, 1-3 parts of adipic acid, 2-5 parts of sebacic acid, 0.001-0.05 part of a special pigment and 10-30 parts of water. The preparation method comprises the following steps: S1, deionized water, the ethylene glycol and the glycerol are added into a main tank, are heated in a 60-70 DEG C water bath for 15-30 min, and the rotating speed is 90-110 r/min; S2, the organic composite additive, the triethanolamine, the special pigment and deionized water are into an auxiliary tank for uniformly stirring at 90-110 r/min; S3, a mixed solution obtained by the S2, the sodium benzoate, the adipic acid and the sebacic acid is added into the mixed solution obtained by the S1, and heating is performed in a 60-70 DEG C water bath for 15-20min at a rotating speed of 300-500 r/min to obtain the syntheticadditive type long-acting antifreeze cooling liquid. According to the method, various components are matched with each other and act synergistically, so the the freezing point and the boiling point ofthe synthetic additive type long-acting antifreeze cooling liquid reach ideal ranges, and the synthetic additive type long-acting antifreeze cooling liquid has long-term corrosion inhibition capability.