The invention relates to the technical field of fresh food packaging processing, in particular to a fresh food cold-chain logistics automatic sealing and packaging system which comprises a first conveying mechanism, a second conveying mechanism, an extrusion device and an extraction device. The second conveying mechanism comprises a second driving motor, a second supporting frame, second supporting legs, second transmission rollers, a second conveying belt, a second main transmission belt, a second auxiliary transmission belt and a packaging box. The extrusion device comprises a rotating motor, a driving gear, a first sliding block, a second sliding block, a first rack, a second rack, a sliding rod, a first supporting rod, a second supporting rod, an extrusion plate, a telescopic rod, a sponge plate and a heat sealing cutter. The extraction device comprises a [-shaped frame, an electric lifting cylinder and a vacuum extractor. In the vacuumizing and sealing packaging process of fresh food, the requirement for large-batch production is met, and the fresh food cold-chain logistics automatic sealing and packaging system has the effects of being high in packaging speed, good in packaging quality and high in packaging continuity.