The invention discloses a chayote liver-soothing cough-relieving lettuce cake and a preparation method thereof. The chayote liver-soothing cough-relieving lettuce cake is prepared from the following raw materials in parts by weight: 6-8 parts of chayote, 10-11 parts of blueberry vinegar, 2-3 parts of shredded green pepper, 1-2 parts of hawthorn, 1-2 parts of rhodiola rosea, 1-2 parts of wolfberry, 70-80 parts of lettuce, 29-300 parts of fresh eggs, 150-160 parts of white granulated sugar, 100-110 parts of flour, 15-20 parts of honey, 5-6 parts of ginseng oligosaccharide, 3-4 parts of pomelo peel dietary fiber, 7-8 parts of soybean protein and appropriate ascorbic acid, phytic acid, citric acid, calcium chloride, beta-cyclodextrin, maltodextrin, absolute ethyl alcohol, yellow wine, blend oil and water. In the invention, the chayote is cut into slices which are mixed with the shredded green pepper, and then the mixture is put into the blueberry vinegar for pickling; after microwave drying, smashing and sieving, the fine powder is fetched; and after the chayote is pickled, the mouthfeel is fresh and crisp and smooth and delicate.