The invention discloses a manufacturing process of high-temperature nodular cast iron. The manufacturing process comprises the steps of (A) mixing materials including scrap steel, pig iron, foundry returns, ferromanganese, silicon carbide, a carburant, ferrosilicon and ferromolybdenum; (B) conducing smelting, specifically, charging the mixed materials into a furnace to be melted into molten iron;(C) conducting heating and standing, heating the molten iron to 1520-1550 DEG C, stopping heating and conducting standing to reach 1460-1480 DEG C; (D) conducting filling, specifically, preheating a casting ladle, filling a nodulizing agent into the pit side of the bottom of the casting ladle, tamping the nodulizing agent with a hammer, covering the nodulizing agent with a layer of nodulizing insulation covering agent, conducting tamping with the hammer, and covering the nodulizing insulation covering agent with a nucleating agent; (E) conducting nodulizing and inoculation, specifically, filling the molten iron into the casting ladle, preventing the molten iron from making contact with the nodulizing agent, adding the nucleating agent again when the molten iron yield is one half of the total treatment amount, stirring the molten iron and then conducting standing for 1.5-3.0 min; (F) conducting casting; and (G) conducting cooling and unpacking. Through the manufacturing process, the microstructure of a casting can be improved to obtain the good graphite from and reduce the pearlite content, the high-temperature strength can be substantially improved, the use requirements are met, and the service life of products is prolonged.