According to the preparation method of the large-tonnage nodular iron casting, the number of balls is large, spheroidization is uniform, spheroidal graphite distortion is small, and the deformation amount of the casting in a casting state is small. The preparation method creatively adopts a ladle-to-ladle spheroidization to adjust the temperature so that the temperature can be controlled, and a four-time composite inoculation block technology is adopted; the number of large-tonnage ductile iron graphite nodules in a cast state is remarkably increased, and finally it can be guaranteed that the number of cast nodules is large, spheroidizing is uniform, deformity is avoided, and the mechanical property is guaranteed; meanwhile, the compacted blocky inoculant is adopted to inoculate the molten iron before and after spheroidizing, slow-release inoculation is achieved through multiple times of slow release, the molten iron fully exists in a temperature and concentration fluctuation area, and therefore the graphite nodules are numerous, round and uniform; according to the method, the spheroidal graphite can be stably obtained, the distortion is small, and the high elastic modulus can be obtained, so that the deformation of a casting in an as-cast state is reduced.