The invention relates to a machining fixture, in particular to an eccentric clamping fixture. The eccentric clamping fixture comprises a base and a threaded column, a hand wheel is fixedly connected at the end of the threaded column, the threaded column is divided into a left part and a right part, each of the two parts is provided with a thread, two sections of the threads are opposite in thread turning direction, each of the left part and the right part is in threaded connection with a clamping plate, ends of the clamping plates are slidably connected with the base while the other ends are used for clamping workpieces, a boss is arranged on the base and between two clamping jaws, the clamping jaws are slidably connected in the boss, a through hole is formed in a drive end of each clamping jaw, a cam matched with the corresponding through hole and capable of locking the corresponding clamping jaw is arranged in the through hole, and the each cam is provided with a handle; the threaded column penetrates driven ends of the clamping jaws, and clamping holes for penetrating of the threaded column are formed in the driven ends of the clamping jaws. By the machining fixture, machining precision under the condition that reacting force in clamping of the workpieces is guaranteed.