The invention discloses a diffusion welding process for a heat exchanger core. The diffusion welding process comprises the following steps: (1) pre-welding pre-treatment: feeding the well assembled heat exchanger core into a diffusion welding furnace, and vacuumizing the interior of the furnace to be below 0.01 Pa; (2) diffusion welding: raising the temperature to 800-850 DEG C at the speed of 15-20 DEG C/min, keeping the temperature for 30 min, after that, raising the temperature to 1,100-1,150 DEG C at the speed of 10-15 DEG C/min, keeping the temperature for 3 h, and performing vacuum cooling to the room temperature, wherein the pressure (8-9.5 MPa) exerted before is kept in the first 2 h and reduced to 4-6 MPa in the last 1 h; and (3) postweld heat treatment: raising the temperature of the heat exchanger core to 1,150-2,000 DEG C, keeping the temperature for at least 20 h, and after that, reducing the temperature in a water quenching manner. According to the diffusion welding process, such parameters as welding temperature, diffusion time and pressure are controlled, the step of heat treatment after diffusion welding is added, so that brittle phases easily generated during diffusion welding are reduced, and the quality of a welded joint of the heat exchanger core is improved.