The invention discloses a spray distillation device, which comprises at least one evaporation chamber, a feed solution inlet pipe, a raw material preheater, a filter, a pump, a feed solution storage tank and a finished product storage tank, wherein the evaporation chamber comprises a shell, a feed solution atomizer, a water vapor distributor and a reflux treatment device; an easy-to-volatilize phase outlet is formed in the top of the shell, and a difficult-to-volatilize phase outlet is formed in the bottom; the feed solution atomizer and the water vapor distributor are mounted in the shell; the feed solution atomizer is connected with the feed solution inlet pipe; the water vapor distributor is connected with a water vapor inlet pipe; the reflux treatment device is mounted in the shell, and consists of a reflux conduit, a water spraying ring, a filler net loop, a residual liquid ventilation cap, a residual liquid discharge pipe and a mounting plate. According to the spray distillation device, a spray distillation technology is adopted instead of an existing mass and heat transfer distillation manner employing an orifice plate or a filler as a main condition, so that heat energy can be completely and effectively utilized, energy resources can be saved, waste liquid discharge reaches the standard, and prominent effects are achieved.