The invention relates to an infusion adverse reaction monitoring and warning device. The device comprises a support, a processing device, a warning device, a gray level probe, a humidity sensor, a temperature sensor, a patch and a heart rate monitoring bracelet, wherein the processing device comprises a storage module, a comprehensive judgement module, a gray level comparison module, a humidity comparison module, a temperature comparison module, a heart rate comparison module, a data acquisition module and a warning information output module. A grey level change value, a humidity change value, a temperature change value and a heart rate change value are measured, then comprehensive judgement is performed, when at least one value is changed relatively greatly, the condition that pale complexion, large sweat amount, sudden cold and heat change or heart rate increase occurs during infusion is indicated, thus, the fact that the adverse reaction is caused by infusion is judged out, warning information is sent to the warning information output module, the warning device emits warning sound, full-automatic monitoring of the infusion adverse reaction is realized, timely warning is performed, nurses are not required to look over patients carefully one by one, and the number and the working intensity of the nurses are substantially reduced.