The invention discloses a mixing material separation and dust-reduction device and application scenarios thereof. The device comprises a multi-channel bionic swirler and an ejector, wherein the multi-channel bionic swirler comprises an overflow tube, a swirl chamber, a shrinking hopper and a sample discharge tube, which are fixedly connected with each other from top to bottom; bionic non-smooth units are distributed on the inner wall surface of the multi-channel bionic swirler; an inlet channel is disposed at the upper end of a side wall of the swirl chamber; the ejector comprises a spray nozzle, a mixing chamber, a throat tube and a diffusion chamber; one end of the spray nozzle is connected with a high-pressure pump, and the other end of the spray nozzle stretches into the interior of the mixing chamber; the mixing chamber is connected with the overflow tube in a closing manner; two ends of the throat tube are respectively connected with the mixing chamber and the diffusion chamber in a closing manner; and the diffusion chamber is connected with a dust-reduction box through a pipeline. The device is mainly used in scenarios in which a large amount of dust is generated such as drilling, geotechnical engineering, grouting engineering, geological disaster control engineering, mining, tunnel piercing and the like, and is capable of solving the technical problems that the existingdevice is low in separation efficiency on mixing materials, unsatisfactory in dust-reduction effect, serious in abrasion, short in service life and the like.