The invention relates to the technical field of poultry breeding, in particular to a breeding method of mule ducks. The method includes the steps: 1) first-generation hybridization; 2) first-generation hybridization; 3) shed building and specie selection; 4) breeding management: breeding the mule ducks according to different ages in days by the aid of feed; 5) duck shed management. The feed of chick ducks is mainly prepared from fish meal, bone meal, protein powder, milk powder, carrot powder, calcium fruits, divaricate saposhnikovia roots, mongolian milkvetch roots, largehead atractylodes rhizomes, spreading hedyotis herbs, common smoketree, chick embryo allantoic fluid, trace elements and the like. The feed of ducks is mainly prepared from corn flour, rice bran, bean pulp, tea seed meal,mushrooms, cholera grass, mustard oil, protein mulberry, winged spindle trees, polygonum aviculare, fructus piperis longi, common aucklandia roots, talcum, ricepaperplant stem-pith, fortune eupatorium herbs, cooking stove earth, trace elements, microbial solution, compound enzyme, iodised salt and the like. According to the breeding method, species of the mule ducks are optimized, growth of the mule ducks is accelerated, the weight of the mule ducks is increased, survival rate is increased, feed cost and use of chemical medicines are reduced, and breeding benefits are improved.