The invention relates to the field of fertilizers and particularly relates to a formula of base fertilizer for oil peony. The formula comprises, by weight, 10 parts of silicon-calcium fertilizer, 30 parts of humic acid-type granular phosphate fertilizer, 40 parts of a soil conditioner, 10 parts of slow-release potassium sulfate, 8 parts of a strain and 2 parts of lauryl alcohol. The used ingredients such as the silicon-calcium fertilizer, humic acid-type granular phosphate fertilizer, soil conditioner, slow-release potassium sulfate and lauryl alcohol satisfy the standard GB21633-2008 and haveeffects of loosening soil, resisting salt and alkali, resisting continuous cropping, improving stress resistance, improving immunity, promoting development, promoting flowers and fruits, strengthening roots and seedlings, adjusting growth and pH and breaking the plow sole. The effective strain can effectively improve the crop resistance to diseases and insects, has a wide prevention and control range, has high activity, produces effects for a long time, effectively improves quality and increases a yield and income.