The invention provides a multi-source multi-detector combined CT system. The system includes a plurality of sets of radiation imaging devices, a data processing unit, a control unit, a rotating machine rack, and a scanning bed; and wherein, each set of the radiation imaging devices includes a detector and a corresponding X-ray source, and at least two of the plurality of sets of radiation imagingdevices are different types of detectors. Based on the multiple radiation imaging devices of the different detectors, the multi-source multi-detector combined CT system is combined, more accurate imaging can be achieved, the comprehensive performance of CT imaging is improved, and mutual calibration, scatter correction, artifact removal, and system image optimization design can be achieved; and atthe same time, by controlling configuration and a scanning mode of different radiation imaging devices, the CT system can be used for the CT Imaging with different, and through combination of a radiation imaging technology of the different types of detectors, and large volume, multi-energy and multi-source precision ultra-fast CT imaging is achieved.