The invention relates to the technical field of noise reduction headphones, in particular to an active noise reduction algorithm and an active noise reduction headphone; the active noise reduction algorithm comprises an acoustic structure, the acoustic structure comprises a front shell and a rear shell, the front shell is provided with a front cavity, the front shell is further provided with a middle cavity, a hole channel and a leakage hole, and a resonance damping loudspeaker box used for installing a loudspeaker is arranged in the middle cavity; wherein the two hole channels are symmetrically arranged; the front shell is further provided with an annular balance sound channel, and the two hole channels are communicated through the annular balance sound channel. According to the active noise reduction algorithm and the active noise reduction earphone, the consistency of the earphone when being designed and worn by a real person can be improved; meanwhile, the reduction degree of the frequency response range is reduced, and the sensitivity of an earphone loudspeaker can be guaranteed. By means of the active noise reduction algorithm, in the noise reduction performance test process, the FF and FB target curves of two pairs of stereo headphones or four TWS headphones can be obtained at the same time in a non-intrusive noise reduction parameter measurement mode, noise reduction microphone signals do not need to be led out from the headphones for measurement, and signals do not need to be emitted to headphone loudspeakers for measurement either.