The invention belongs to the technical field of toxin degradation, and discloses application of lactobacillus acidophilus in degradation of fungal toxins in animal bodies. The fungal toxins comprise T-2 toxins, aflatoxin B1, deoxynivalenlo and ochratoxin; lactobacillus acidophilus liquid is uniformly sprayed to animal feed, litopenaeus vannamei and tilapia mossambica are fed with feed containing lactic acid bacteria and feed containing the T-2 toxins, the aflatoxin B1 (AFB1), the deoxynivalenlo (DON) and the ochratoxin (OTA) for ten days, and fungal toxin residues in the muscles of the litopenaeus vannamei and the tilapia mossambica are significantly reduced compared with a control group, wherein the T-2 content in the litopenaeus vannamei muscles is decreased by 63.86%+/-1.32%, the AFB1 content in the litopenaeus vannamei muscles is decreased by 53.04%+/-0.97%, the DON content in the litopenaeus vannamei muscles is decreased by 70.74%+/-1.47%, the OTA content in the litopenaeus vannamei muscles is decreased by 70.24%+/-1.22%, the T-2 content in the tilapia mossambica muscles is decreased by 54.93%+/-2.52%, the AFB1 content in the tilapia mossambica muscles is decreased by 42.10%+/-1.97%, the DON content in the tilapia mossambica muscles is decreased by 48.75%+/-0.93%, and the OTA content in the tilapia mossambica muscles is decreased by 32.79%+/-1.81%. Accordingly, the lactobacillus acidophilus is prepared into a feed additive, then the fungal toxins accumulated in the animal bodies can be degraded, and the practical application value is achieved.