The invention discloses a sugarless chewing gum with functions of internal heat clearing and inflammation relieving and a preparation method thereof. The sugarless chewing gum comprises, by weight, 10-20 parts of medicinal powder, 25-35 parts of a gelatin medium, 5-15 parts of xylitol, 35-45 parts of sorbitol, 5-15 parts of mannitol, 5-15 parts of a maltitol slurry and 3-5 parts of a flavoring agent, wherein the medicinal powder is prepared from 10-25 parts of Sterculia lychnophora, 20-40 parts of aloe leaf, 10-25 parts of ginkgo seed, 10-25 parts of ginkgo leaf, 10-25 parts of mint leaf, 10-25 parts of honeysuckle flower, 10-20 parts of wild chrysanthemum flower, 15-25 parts of lemon essential oil, 15-25 parts of mint essential oil, 10-20 parts of rosemary essential oil, 3-5 parts of clove seed essential oil, 3-5 parts of eucalyptus leaf essential oil and 3-5 parts of tea tree essential oil. Compared with traditional chewing gums, the chewing gum of the invention, which reduces sugar intake and introduces a pure traditional Chinese medicinal preparation with the functions of internal heat clearing and inflammation relieving, effectively solves problems of uncontinuous dosing, short lasting time of medicinal effects, bad curative effect and the like of traditional oral inflammation treatment methods without influencing the mouthfeel and tooth cleaning, overcomes disadvantages in the prior art, and broadens the audience of chewing products.