The invention discloses a silk-screen printing ink. The silk-screen printing ink is prepared from the following raw materials in parts by weight: 35-50 parts of polyester resin, 10-15 parts of styrene-acrylic resin, 20-35 parts of butyl cellosolve, 10-25 parts of a pigment, 8-15 parts of a filler, 0.5-3 parts of a dispersant, 0.5-3 parts of a defoamer, 1-3 parts of 2,4-dihydroxy benzophenone and 0.5-2 parts of castor oil. A preparation process of the silk-screen printing ink comprises the following steps: preparation of a resin solution, dispersion, grinding, filtering, packaging and the like.According to the silk-screen printing ink, as polyester resin and styrene-acrylic resin are taken as vehicles, no toxin, harm or VOC pollution is caused; the silk-screen printing ink has favorable adhesiveness on such printing stocks as a PVC panel and a thin film panel, is definite in image and text and free from after-tacking and dampness, cannot be dyed after being scoured, and particularly, has favorable printing fluidity and glossiness under high-temperature and high-humidity, or low-temperature and low-humidity environmental conditions; and the preparation process of the silk-screen printing ink is simple to process and suitable for large-scale production.