The invention discloses an experimental device for synthesizing marine natural gas hydrate samples, which comprises a reaction kettle, an axial pressure piston, an outer jacket of the kettle, an injection system, an axial pressure control system, a confining pressure control system and an output system. The invention also discloses an experimental method for preparing marine natural gas hydrate samples by using the above-mentioned experimental device. Firstly, ice powder particles are made, and then the ice powder particles are mixed with dried porous medium particles, and placed in a low temperature environment below zero. In the high-pressure reactor to simulate the geomechanical properties of the seabed, methane gas is injected to generate hydrate, and the ice is directly converted into hydrate. Finally, the free gas in the reactor is driven out through the liquid injection system. The present invention can economically, effectively and accurately obtain real marine natural gas hydrate samples under various geological conditions and various occurrence conditions that are difficult to obtain, making hydrate research closer to reality, and providing research on natural gas hydrate exploitation. Experimental basis.