The invention discloses a display panel, a displayer, a manufacturing method and a liquid crystal medium mixture. The display panel comprises a first substrate, a second substrate opposite to the first substrate, and a liquid crystal layer arranged between the first substrate and the second substrate. A plurality of polymer retaining walls are arranged in the liquid crystal layer and are in contact with the first substrate and the second substrate, and the polymerization direction of polymerizable monomers in the polymer retaining walls is perpendicular to the thickness direction of the polymer retaining walls. According to the display panel, the displayer, the manufacturing method and the liquid crystal medium mixture, the polymer retaining walls are arranged in the liquid crystal layer,therefore, flowing of liquid crystals in the liquid crystal layer is limited, polymerization of the polymerizable monomers in the polymer retaining walls has directionality, the roughness of the edgesof the polymer retaining walls is relieved, pixel edge light leakage is relieved, and the display effect is improved.