The invention relates to message switching equipment for networked settlement of social security and medical insurance. The message switching equipment comprises a plurality of groups of data switching modules which are connected with one another, wherein each data switching module comprises an input unit, an authentication unit, a processing unit, an underlying communication unit, a network segment configuration unit, a journal unit and an output unit, and is connected with a data transmission network or an application server for data transmission and data switching. The message switching equipment adopts a four-layer structure, namely, asocial security and medical insurance networked settlement interface, a data switching layer configuration management device, a central data switching and processing unit and a message switching operation system. The invention aims to achieve real-time networking and unified settlement of a larger administrative region, utilizes the centralized data switching application mode to achieve regional social security and medical insurance networked settlement service, provides a reliable data switching mechanism for social security and medical insurance networked settlement, ensures high efficiency of the networked settlement and data switching, and has a favorable interface expansibility.