A multi-layer film for vertical form, film and seal systems for liquid, powder, granules and/or other flowables packaging, said multi-layer comprising: an inner layer made of polyethylene, a blend of polyethylenes or ethylene copolymers; a core, comprising one or more than one layer, made from a blend of polypropylene, linear low density polyethylene, a polymer compatibilizer or tie-layer resin, and/or low density polyethylene, said core being applied against the inner layer; and an outer layer (same or different from the inner layer or the core layer) is made of a polyethylene or a blend of polyethylenes with or without ethylene copolymers, said outer layer being applied against the core and opposite the inner layer; said multi-layer film having an overall thickness of lower or equal to 2.5 mil and at least one of the properties listed hereinafter: a stiffness (as measured by 1% secant modulus in the film direction) varying from 79000 psi to 140000 psi; a tensile strength at yield of from 2100 psi to 3300 psi; (measured in film machine direction) and a tensile strength at break of from 4700 to 6700 psi (measured in film machine direction). A method of forming, sealing and filling a pouch with said film, a pouch formed with said film and use of said film to form a pouch.