The present invention discloses enzyme Laiyang pear paste and a preparation method and an application thereof. The disclosed Laiyang pear paste is prepared by low-temperature fermentation of 7-14 jin of Laiyang pears and 1 part of traditional Chinese medicine decoction, and low-temperature and negative-pressure distillation and concentration. The enzyme Laiyang pear paste is characterized in that, the 1 part of the traditional Chinese medicine decoction is prepared by boiling the following medicinal materials: 8-13 grams of each of liquorice, dried gingers, red dates, buckwheat, radix puerariae, haws, smoked plums, wrinkled gianthyssop herbs, fructus amomi, poria cocos, Chinese wolfberry fruits, chrysanthemums, and fructus momordicae, 4-8 grams of semen sterculiae lychnophorae, 2-5 grams of each of rhizoma imperatae and bulbus lilii, and 5-9 grams of radix platycodonis. The present invention also discloses the preparation method of the Laiyang pear paste. Compared with the prior art, the active plant enzymes of the pear paste has effects of moistening lungs and stopping cough, clearing and benefiting throats, reducing fire and promoting salivation, harmonizing stomach and reducing phlegm, beautifying features and nourishing skins, preventing and treating haze syndromes, relieving toxins, lowering blood lipids, blood pressure, and cholesterol, and more effectively preventing and curing cancers, liver and kidney diseases, etc.