The invention discloses a low-cost high-recovery environment-friendly mineral separation method of low-grade vanadium titano-magnetite. Medium-intensity magnetic primary iron separation, large-particle strong-magnetic tail throwing, subsequent ore grinding magnetic separation iron separation, strong-magnetic flotation titanium separation are conducted after three segments of crushing including rough crushing, medium crushing and high-pressure roller grinding are conducted, the iron and titanium ore concentrate quality and yield are higher, energy consumption per unit is lower, tailings discharge pressure is smaller, and the production capacity is greatly improved. According to the method, qualified tailings are thrown out in advance through the method that medium-intensity magnetic primary iron separation and strong-magnetic tail throwing are conducted after fine crushing is conducted, so that the subsequent ore grinding amount is reduced, the grade of iron and titanium generated in the subsequent grinding and separation processes is increased, and thus the product cost is reduced. The method is simple in technological process, easy to operate, low in cost and high in ore separation efficiency, the produced product is stable in performance, the production environment is more environmentally friendly, chemical matter generated in the flotation titanium separation production process is greatly reduced, and the pollution is low. The method is not limited by the production scale, the iron and titanium ore concentrate quality and yield are increased while large-particle qualified tailings can serve as by products to increase benefits, so that the enterprise profits can be maximized, and the method has wide application prospects on the aspect of vanadium titano-magnetite separation.