50 results about "Aspergillus aculeatinus" patented technology

The invention discloses a method for producing cellulose and polypeptide protein feed by fermenting with Aspergillus awamori 1042-2 which belongs to the Aspergillus and has the collection registration number of M209142 in the China Center for Type Culture Collection (CCTCC). The method for producing the cellulose and the polypeptide protein feed comprises the following steps: A, selecting the Aspergillus awamori 1042-2; B, authenticating the Aspergillus awamori 1042-2, C, culturing the Aspergillus awamori 1042-2 liquid; D, fermenting the solid material; and F, postprocessing. The solid culture which is obtained by inoculating the Aspergillus awamori 1042-2 onto the solid culture medium and fermenting the Aspergillus awamori 1042-2 and the solid culture medium is baked to dry, ground, sieved and subjected to the detection of the enzyme activity and the polypeptide protein content. The method for producing the cellulose and the polypeptide protein feed is feasible and easy, the produced powdered cellulose has the CMC enzyme activity of 31397.1-41826.7 U/g and the FPA enzyme activity of 1779.3-2212.1 U/g, has good stability and can be produced on a large scale, and the produced polypeptide protein feed contains more than 35 percent of protein. The Aspergillus awamori 1042-2 can be used for fermenting the palm kernel dregs, other dregs and the vegetable fiber and producing the biological feed, the biological fertilizer, the biological fuel and can be also used in the food industry, chemical industry and the pharmaceutical industry. The polypeptide protein feed produced by fermenting with the Aspergillus awamori 1042-2 can be used as the additive of the protein of various feed.

The invention belongs to the technical field of microorganisms, and relates to marine-derived Aspergillus terreus M7 with an antibacterial effect, and separation and application of a secondary metabolite of the Aspergillus terreus M7. The strain is classified and named as Aspergillus terreus M7, and is preserved in China Center for Type Culture Collection (CCTCC) on June 7, 2021, with the preservation number of CCTCC NO: M 2021679. The strain is fermented by a soybean solid culture medium, and is subjected to methanol extraction, silica gel G chromatography, Sephadex LH-20 gel column chromatography, silica gel H chromatography and preparative liquid phase separation and purification to obtain a compound terramide A. The terramide A has obvious antibacterial activity on acinetobacter baumannii ATCC 19606, and has the potential of being developed into an antibacterial agent.

The present invention provides monoclonal antibodies specific for members of the Aspergillus genus and uses thereof for increasing the survival rate of a subject infected with an Aspergillus species. The present invention also provides conjugates of alliinase with monoclonal antibodies specific for members of the Aspergillus genus that preserve the ability of the antibody to recognize the fungus as well as the activity of the enzyme to produce cytotoxic molecules of allicin from the substrate alliin. The invention further provides pharmaceutical compositions comprising the conjugates of the mAbs of the invention and alliinase and uses thereof in combination with the substrate alliin in the treatment of diseases cause by Aspergillus species, in particular invasive aspergillosis.

The invention relates to an Aspergillus fungus (Aspergillus sp.EGF15-0-3) and an application thereof. The Aspergillus fungus is preserved at the Guangdong Provincial Microbial Culture Collection Center, and a preservation number is GDMCC 60476. The Aspergillus fungus (Aspergillus sp.EGF15-0-3) of the invention can be used to prepare benzaldehyde ylide heterodimer compounds, a renewable biologicalsource is provided for rare natural products, and thereby a sufficient material basis is provided for further biological activity researches and biological applications of the rare natural products.

The invention provides a compound as well as a synthetic gene cluster and an application thereof. The compound is prepared from a precursor compound aspergidienes A-D and a sesterterpene compound aspergiols A-D, and the aspergiols A-D has the anti-tumor activity, and the sesterterpene compound aspergiols A-D has the anti-tumor activity. The biosynthetic gene cluster SAC11189 composed of a terpenesynthase gene Au11189 and a cytochrome P450 enzyme gene Au11188 is obtained in aspergillus fungi 094102 through genome mining. An aspergillus oryzae expression system is used for expressing each genein a gene cluster to obtain four sesquiterpene compounds aspergiols A-D with novel structures. In-vitro cytotoxic activity test results show that the assergils A-D shows different degrees of inhibitory activity on a plurality of tumor cells, and a possible candidate compound is provided for the development of novel anti-tumor drugs.

The invention discloses a strain composition and application thereof as well as a preparation method and application of medicated leaven. The strain composition comprises peritoneum fibuligerum and bacillus subtilis. The strain composition is safe and harmless, has protease and amylase production activity, can be symbiotic and can improve the enzyme activity of medicated leaven, and compared with existing aspergillus fungi used for synergistic fermentation, the yeast fungi avoid production of mycotoxin and are safer.

The invention relates to a ratio fluorescence biosensor based on gold nanoclusters, a preparation method of the ratio fluorescence biosensor and application of the ratio fluorescence biosensor to detection of aspergillus mycetes. The method comprises the following steps: by taking an aspergillus mould DNA genome as a target, designing an LAMP primer, and adding FITC-coated AuNCs on the basis of determining the specificity of the primer to carry out LAMP reaction. AuNCs protected by BSA is used as a fluorophore, FITC is used as a pH response signal, along with LAMP reaction, a large number of pyrophosphate and hydrogen ions are released, the ratio fluorescence signals of FITC and AuNCs are gradually reduced, and the method can be used for quantitative analysis of aspergillus mould detection.

The invention discloses a complex vitamin D for preventing and treating fungal infection. The complex vitamin D comprises functional components of vitamin D2 and a vitamin D3 in the mass ratio of thevitamin D2 to the vitamin D3 being (1-3) to (1-5). The invention further discloses an application of the complex vitamin D to preparation of a medicine for preventing and treating fungal infection. The complex vitamin D has the effects of preventing and treating infection of aspergillus, cryptococcus neoformans and the like. The compound is low in cytotoxicity and can be used as a candidate for treatment of clinical anti-fungal infection.