According to the technical scheme, the sky-ground integrated monitoring method comprises the steps that S1, firstly, infected and withered trees are extracted through unmanned aerial vehicle images, plaques of the infected and withered trees are extracted through satellite images, and on-site marking, positioning and measuring are conducted on the withered trees through ground investigation; s2, respectively acquiring high-spatial-resolution satellite remote sensing data and unmanned aerial vehicle remote sensing data as data sources, and jointly forming a data set of a monitoring area in combination with ground survey data and forest resource second-class survey data; s3, establishing samples of the epidemic trees according to the data, wherein the samples comprise spectral features, texture features and geometric features of the pine wood nematode disease withered and dead trees; and S4, according to the sample and satellite remote sensing, confirming the infected, withered and dead tree plaques, comprehensively applying an image enhancement and image classification method, performing verification, and establishing spatial distribution information and position information of the pine wood nematode disease withered and dead trees. The method has the advantages of high epidemic area screening efficiency, capability of realizing large-area efficient monitoring, convenience in acquisition of remote sensing data of the unmanned aerial vehicle, high recognition precision and guarantee for precision verification.