The invention relates to a machining method of a universal die holder. The machining method comprises the following steps: step 1, performing rough machining operation on upper and lower end surfacesand four circumferential surfaces of a movable template and a fixed template; step 2, centering and boring the movable template and the fixed template and respectively finding out centers of the movable template and the fixed template; step 3, fixing the movable template and the fixed template to a CNC machining center above and below, enabling the centers of the movable template and the fixed template to be superpose vertically meanwhile guide column holes of the movable template and the fixed template are machined with the center of the movable template as a central point; step 4, continuingto ream the guide column holes with the center of a guide column hole of the movable template as the center and machining guide sleeve holes; step 5, machining guide sleeves; step 6, machining guidecolumns; step 7, assembling the movable template, the fixed template, the guide columns and the guide sleeves to be a die holder. Firstly, the movable template and the fixed template are drilled withthe guide column holes. Secondly, reaming operation is carried out on the guide column hole in the movable template. Therefore, relative precision between the guide column holes and the guide sleeve holes is ensured.