The invention relates to a heat-insulated refrigerator for medical medicine, comprising a box body with an opening, and a cover body sealingly fitted with the opening; the box body is sequentially composed of a hard polyurethane layer and a vacuum insulation board layer , foamed polyurethane board and shell. In the heat-insulating refrigerated box of the present invention, since the vacuum insulation board layer and the rigid polyurethane layer are arranged in the polyurethane foam plastic layer to form a composite heat-insulating structure, not only the thickness of the heat-insulated refrigerated box is reduced, but also the same appearance The effective volume of the insulation box is greatly improved, and its thermal insulation coefficient is less than or equal to 0.004W / mK, which can effectively prevent heat radiation, heat conduction and heat convection between the inside of the box and the external environment. The heat insulation box can ensure that the temperature inside the box is within At 2-8°C, the duration is more than 120 hours; the insulated refrigerator of the present invention is mainly used for refrigeration and freezing of vaccines, insulin, blood products, biological products, reagents and other medicines during transportation and storage.