A precision adjusting device for large-sized gratings comprises a grating mounting frame, grating positioning jackscrews, a grating pitching adjustment platform, a mounting base, a displacement fine-adjustment knob, a displacement fine-adjustment knob positioning jackscrew, an ejector disc, a tension spring, a tension spring support rod, a gear set, a transmission screw, bearings, a guide, keys, an angular fine-adjustment knob, a driving gear positioning block, and a level. The precision adjusting device for large-sized gratings has the advantages of simple structure, convenience in operation and high adjustment precision, and is applicable to optical systems with large-sized gratings requiring precision tuning.