The invention provides a light-emitting diode (LED)-exposed waterproof perforated lamp string and a manufacturing method thereof. The LED-exposed waterproof perforated lamp string is formed by combining LED lamps, printed circuit boards (PCBs) and anti-ultraviolet (anti-UV) polyurethane (PU) wires together in a welding mode and an epoxy resin glue embedment mode and solidifying at the high temperature of between 50 and 60 DEG C. The problem that modified epoxy resin and polyvinyl chloride (PVC) cables cannot be firmly adhered and the problem of waterproof performance treatment are radically solved. When the LED-exposed waterproof perforated lamp string is actually used, a plurality of perforated lamps are connected together by a parallel circuit according to a certain rule; the LED-exposed waterproof perforated lamp string has the advantages of simple structure, low cost, long service life, large light-emitting angle, low light attenuation, uniform aperture, low power consumption, energy conservation and environment friendliness, is stable in work and safe in use and is driven by direct current (DC) the constant voltage of 5V; and a special bayonet design is adopted, and the perforated lamps are directly mounted after being perforated, so that mounting cost is lowered, the LED-exposed waterproof perforated lamp string is convenient to maintain, and various boards can be used after being perforated. The perforated lamps are designed in a bidirectional disassembling and assembling separated mode, so that the perforated lamps are easier to maintain and have wide application prospects.